周树堂，博士，教授，博士生导师。中国科学院“百人计划”-引进国外杰出人才（A类），入选“国家百千万人才工程”，授予“国家有突出贡献中青年专家”，获“国务院政府特殊津贴”。2002年毕业于加拿大女皇大学(Queen’s University)，获生物化学与分子生物学博士学位。曾担任美国杜克大学助理教授，中国科学院动物研究所研究员，博士生导师，研究组长，河南农业大学生命科学院院长。目前被聘为河南大学“杰出人才特区支持计划”特聘教授，担任河南大学棉花生物学国家重点实验室和教育部植物逆境生物学重点实验室副主任。兼任中国昆虫学会理事，发育与遗传专业委员会副主任，国际交流与合作工作委员会副主任，基因组专业委员会委员，Archive of Insect Biochemistry and Physiology编委等。
一、研究方向
长期从事植物保护和昆虫学研究，运用基因组学、分子生物学、细胞生物学、遗传学等手段，解析昆虫生殖发育的内分泌调控机制、植物—昆虫—微生物互作以及害虫与天敌昆虫互作的分子机制。
二、研究工作经历
2015-至今，河南大学生命科学学院，植物逆境生物学重点实验室，副主任，教授
2010–2015，中国科学院动物研究所，研究员，研究组组长
2005–2010，美国杜克大学(Duke University)，助理教授，助理研究员
2007–2009，河南农业大学生命科学院，院长（兼）
2003–2004，加拿大皇后大学，生物化学系与蛋白质功能中心，博士后
三、主要研究项目
1. NSFC-河南联合基金重点项目，群居型飞蝗迁飞的分子调控机制（U1804232），直接经费209万元，2019.01-2022.12。
2. 国家基金委重点项目，飞蝗对环境变化生殖适应的内分泌调控机制研究（31630070），2017.01-2021.12，直接经费277万元。
3. 国家基金委面上项目，飞蝗卵子发生的microRNA调控机制研究（31372258），2014.01–2017.12，82万元。
4. 国家基金委面上项目，飞蝗性成熟期保幼激素作用的分子机制研究（31172149），2012.01-2015.12，61万元。
5. 国家“973” 项目子课题，害虫发育与变态的遗传机制（2012CB114101），2012.01－2016.12，100万元。
6. 中国科学院“百人计划”择优支持，2011.08- 2014.07，200万元。
7. 河南省高校科技创新团队支持计划，农业昆虫与害虫防治（16IRTSTHN011），2016.01-2017.12，100万元。
四、代表性论文（*通讯作者）
1. Guo W, Wu Z, Yang L, Cai Z, Zhao L, Zhou S*. 2019. Juvenile hormone-dependent Kazal-type serine protease inhibitor Greglin safeguards insect vitellogenesis and egg production. FASEB J. 33(1): 917-927. doi: 10.1096/fj.201801068R.
2. Song J, Li W, Zhao H, Gao L, Fan Y, Zhou S*. 2018. MicroRNA let-7 and miR-278 regulate insect metamorphosis and oogenesis via targeting juvenile hormone early response gene Krüppel-homolog 1. Development. 2145(24). doi: 10.1242/dev.170670.
3. Song J, Li W, Zhao H, Zhou S*. 2018. Clustered miR-2, miR-13a, miR-13b and miR-71 coordinately target Notch gene to regulate oogenesis of the migratory locust Locusta migratoria. Insect Biochem Mol Biol. doi: 10.1016/j.ibmb.2018.11.004.
4. Jing YP, An H, Zhang S, Wang N, Zhou S*. 2018. Protein kinase C mediates juvenile hormone-dependent phosphorylation of Na+/K+-ATPase to induce ovarian follicular patency for yolk protein uptake. J Biol Chem. 293(52): 20112-20122. doi: 10.1074/jbc.RA118.005692.
5. Wu Z, Guo W, Yang L, He Q, Zhou S*. 2018. Juvenile hormone promotes locust fat body cell polyploidization and vitellogenesis by activating the transcription of Cdk6 and E2f1. Insect Biochem Mol Biol. 102: 1-10.
6. Luo M, Li D, Wang Z, Guo W, Kang L*, Zhou S*. 2017. Juvenile hormone differentially regulates two Grp78 genes encoding protein chaperones required for insect fat body cell homeostasis and vitellogenesis. J Biol Chem. 292(21): 8823-34.
7. Wang Z, Yang L, Song J, Kang L*, Zhou S*. 2017. An isoform of Taiman that contains a PRD-repeat motif is indispensable for transducing the vitellogenic juvenile hormone signal in Locusta migratoria. Insect Biochem Mol Biol. 82, 31-40.
8. Du M, Liu X, Ma N, Liu X, Wei J, Yin X, Zhou S, Ada R, Song Q, An S. 2017. Calcineurin-mediated dephosphorylation of Acetyl-coA Carboxylase is required for pheromone biosynthesis activating neuropeptide (PBAN)-induced sex pheromone Biosynthesis in Helicoverpa armigera. Mol Cell Proteomics. 16(12):2138-2152.
9. Wu Z, Guo W，Xie Y, Zhou S*. 2016. Juvenile hormone activates the transcription of Cell-division-cycle 6 (Cdc6) for polyploidy-dependent insect vitellogenesis and oogenesis. J Biol Chem. 291(10): 5418-27.
10. Guo W, Wu Z, Song J. Jiang F, Deng S, Walker VK, Zhou S*. 2014. Juvenile hormone-receptor complex acts on Mcm4 and Mcm7 to promote polyploidy and vitellogenesis in the migratory locust. PLoS Genetics. 10(10): e1004702.
11. Song J, Wu Z, Wang Z, Deng S, Zhou S*. 2014. Krüppel-homolog 1 mediates juvenile hormone action to promote vitellogenesis and oocyte maturation in the migratory locust. Insect Biochem Mol Biol. 52: 94-101.
12. Liu L, Zheng H, Jiang F, Guo W, Zhou S*. 2014. Comparative transcriptional analysis of asexual and sexual morphs reveals possible mechanisms in reproductive polyphenism of the cotton aphid. PLoS ONE. 9(6): e99506.
13. Ren D, Cai Z, Song J, Wu Z, Zhou S*. 2014. dsRNA uptake and persistence account for tissue-dependent susceptibility to RNA interference in the migratory locust, Locusta migratoria. Insect Mol Biol. 23(2): 175–184.
14. Song J, Guo W, Jiang F, Kang L, Zhou S*. 2013. Argonaute 1 is indispensable for juvenile hormone mediated oogenesis in the migratory locust, Locusta migratoria. Insect Biochem Mol Biol. 43(9): 879-887.
15. Zhou S*, Nissao E, Jackson IL, Leong W, Dancy L, Cuttitta F, Vujaskovic Z, Sunday ME*. Radiation-induced lung injury is mitigated by blockade of gastrin-releasing peptide. Am J Pathol. 2013. 182(4):1248-1254.
16. Zhou S, Degan S, Potts EN, Foster FM, Sunday ME. 2009. NPAS3 is a trachealess homolog critical for lung development and homeostasis. Proc Natl Acad Sci USA. 106(28), 11691-11696. Recommended by “Faculty of 1000”.
17. Levesque BM#, Zhou S#, Shan L, Kong Y, Sunday ME. 2007. NPAS1 regulates branching morphogenesis in embryonic lung. Am J Respir Cell Mol Biol. 36(4), 427-434. #Co-first authors.
18. Zhou S, Tejada M, Wyatt GR, Walker VK. 2006. A DNA-binding protein, tfp1, involved in juvenile hormone-regulated gene expression in Locusta migratoria. Insect Biochem Mol Biol. 36: 724-734.
19. Zhou S, Webb BA, Eves R, Mak AS. 2006. Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells. Am J Physiol Cell Physiol. 290, C463-471.
20. Webb BA, Zhou S, Eves R, Shen L, Jia L, Mak AS. 2006. Phosphorylation of cortactin by p21-activated kinase. Arch Biochem Biophys. 456, 183-193.
21. Eves R, Webb BA, Zhou S, Mak AS. 2006. Caldesmon is an integral component of podosomes in smooth muscle cells. J Cell Sci. 119, 1691-1702.
22. Webb BA, Eves R, Crawley SW, Zhou S, Côté GP, Mak AS. 2005. PAK1 induces podosome formation in A7r5 vascular smooth muscle cells in a PAK-interacting exchange factor-dependent manner. Am J Physiol Cell Physiol. 289: C898-907.
23. Hayward DC, Dhadialla TS, Zhou S, Kuiper MJ, Ball EE, Wyatt GR, Walker VK. 2003. Ligand specificity and developmental expression of RXR and ecdysone receptor in the migratory locust. J Insect Physiol. 49, 1135-1144.
24. Zhou S, Zhang J, Hirai M, Chinzei Y, Kayser H, Wyatt GR, Walker VK. 2002. A DNA-binding protein involved in gene regulation by juvenile hormone. Mol Cell Endocrinol. 190, 177-185.
25. Zhou S, Zhang J, Fam MD, Wyatt GR, Walker VK. 2002. Sequences of elongation factors-1a and -1g and stimulation by juvenile hormone in Locusta migratoria. Insect Biochem Mol Biol. 32, 1567-1576.
